| QB Rookies = 1.80 Unlisted = 0.01 | PASSING | RUSHING | POINTS | ||||||||||||
| PLAYER | TEAM | G | CMP | YDS | TD | INT | YDS | TD | Comp | Yds | TD | Int | Total | Salary | |
| Drew Brees | NO | 16 | 468 | 5476 | 46 | 14 | 86 | 1 | 468 | 37 | 282 | -28 | 759 | 6.05 | |
| Matthew Stafford | DET | 16 | 421 | 5038 | 41 | 16 | 78 | 0 | 421 | 34 | 246 | -32 | 669 | 5.33 | |
| Tom Brady | NE | 16 | 401 | 5239 | 39 | 12 | 108 | 3 | 401 | 36 | 252 | -24 | 665 | 5.30 | |
| Aaron Rodgers | GB | 15 | 343 | 4643 | 45 | 6 | 257 | 3 | 343 | 33 | 288 | -12 | 652 | 5.19 | |
| Tony Romo | DAL | 16 | 346 | 4184 | 31 | 10 | 46 | 1 | 346 | 28 | 192 | -20 | 546 | 4.35 | |
| Eli Manning | NYG | 16 | 359 | 4933 | 29 | 16 | 15 | 1 | 359 | 33 | 180 | -32 | 540 | 4.30 | |
| Matt Ryan | ATL | 16 | 347 | 4177 | 29 | 12 | 84 | 2 | 347 | 28 | 186 | -24 | 537 | 4.28 | |
| Philip Rivers | SD | 16 | 366 | 4624 | 27 | 20 | 36 | 1 | 366 | 31 | 168 | -40 | 525 | 4.18 | |
| Cam Newton | CAR | 16 | 310 | 4051 | 21 | 17 | 706 | 14 | 310 | 32 | 210 | -34 | 518 | 4.13 | |
| Mark Sanchez | NYJ | 16 | 308 | 3474 | 26 | 18 | 103 | 6 | 308 | 24 | 192 | -36 | 488 | 3.89 | |
| Ryan Fitzpatrick | BUF | 16 | 353 | 3832 | 24 | 23 | 215 | 0 | 353 | 27 | 144 | -46 | 478 | 3.81 | |
| Ben Roethlisberger | PIT | 15 | 324 | 4077 | 21 | 14 | 70 | 0 | 324 | 28 | 126 | -28 | 450 | 3.58 | |
| Josh Freeman | TB | 15 | 346 | 3592 | 16 | 22 | 238 | 4 | 346 | 26 | 120 | -44 | 448 | 3.57 | |
| Joe Flacco | BAL | 16 | 312 | 3610 | 20 | 12 | 88 | 1 | 312 | 25 | 126 | -24 | 439 | 3.50 | |
| Andy Dalton | CIN | 16 | 300 | 3398 | 20 | 13 | 152 | 1 | 300 | 24 | 126 | -26 | 424 | 3.38 | |
| Matt Hasselbeck | TEN | 16 | 319 | 3571 | 18 | 14 | 52 | 0 | 319 | 24 | 108 | -28 | 423 | 3.37 | |
| Alex Smith | SF | 16 | 274 | 3150 | 17 | 5 | 179 | 2 | 274 | 22 | 114 | -10 | 400 | 3.19 | |
| Michael Vick | PHI | 13 | 253 | 3303 | 18 | 14 | 590 | 1 | 253 | 26 | 114 | -28 | 365 | 2.91 | |
| Tarvaris Jackson | SEA | 15 | 271 | 3091 | 14 | 13 | 108 | 1 | 271 | 21 | 90 | -26 | 356 | 2.84 | |
| Rex Grossman | WAS | 14 | 265 | 3151 | 16 | 20 | 11 | 1 | 265 | 21 | 102 | -40 | 348 | 2.77 | |
| Colt McCoy | CLE | 13 | 265 | 2733 | 14 | 11 | 214 | 0 | 265 | 20 | 84 | -22 | 347 | 2.76 | |
| Matt Moore | MIA | 13 | 193 | 2330 | 16 | 8 | 66 | 2 | 193 | 16 | 108 | -16 | 301 | 2.40 | |
| Matt Schaub | HOU | 10 | 178 | 2479 | 15 | 6 | 9 | 2 | 178 | 17 | 102 | -12 | 285 | 2.27 | |
| Blaine Gabbert | JAC | 15 | 210 | 2214 | 12 | 11 | 98 | 0 | 210 | 15 | 72 | -22 | 275 | 2.19 | |
| Carson Palmer | OAK | 10 | 199 | 2753 | 13 | 16 | 20 | 1 | 199 | 18 | 84 | -32 | 269 | 2.14 | |
| Jay Cutler | CHI | 10 | 182 | 2319 | 13 | 7 | 55 | 1 | 182 | 16 | 84 | -14 | 268 | 2.13 | |
| Tim Tebow | DEN | 14 | 126 | 1729 | 12 | 6 | 660 | 6 | 126 | 16 | 108 | -12 | 238 | 1.90 | |
| Sam Bradford | STL | 10 | 191 | 2164 | 6 | 6 | 26 | 0 | 191 | 15 | 36 | -12 | 230 | 1.83 | |
| Christian Ponder | MIN | 11 | 158 | 1853 | 13 | 13 | 219 | 0 | 158 | 14 | 78 | -26 | 224 | 1.78 | |
| Matt Cassel | KC | 9 | 160 | 1713 | 10 | 9 | 99 | 0 | 160 | 12 | 60 | -18 | 214 | 1.70 | |
| John Skelton | ARI | 8 | 151 | 1913 | 11 | 14 | 128 | 0 | 151 | 14 | 66 | -28 | 203 | 1.62 | |
| Kyle Orton | DEN | 9 | 150 | 1758 | 9 | 9 | 13 | 0 | 150 | 12 | 54 | -18 | 198 | 1.58 | |
| Kevin Kolb | ARI | 9 | 146 | 1955 | 9 | 8 | 65 | 0 | 146 | 13 | 54 | -16 | 197 | 1.57 | |
| Curtis Painter | IND | 9 | 132 | 1541 | 6 | 9 | 107 | 0 | 132 | 11 | 36 | -18 | 161 | 1.28 | |
| Dan Orlovsky | IND | 8 | 122 | 1201 | 6 | 4 | 5 | 0 | 122 | 8 | 36 | -8 | 158 | 1.26 | |
| Jason Campbell | OAK | 6 | 100 | 1170 | 6 | 4 | 60 | 2 | 100 | 8 | 48 | -8 | 148 | 1.18 | |
| Donovan McNabb | MIN | 6 | 94 | 1026 | 4 | 2 | 59 | 1 | 94 | 7 | 30 | -4 | 127 | 1.01 | |
| John Beck | WAS | 4 | 80 | 858 | 2 | 4 | 43 | 2 | 80 | 6 | 24 | -8 | 102 | 0.81 | |
| Taylor Yates | HOU | 6 | 82 | 949 | 3 | 3 | 57 | 0 | 82 | 7 | 18 | -6 | 101 | 0.80 | |
| Chad Henne | MIA | 4 | 64 | 868 | 4 | 4 | 112 | 1 | 64 | 7 | 30 | -8 | 93 | 0.74 | |
| Tyler Palko | KC | 6 | 80 | 796 | 2 | 7 | 15 | 0 | 80 | 5 | 12 | -14 | 83 | 0.66 | |
| Vince Young | PHI | 7 | 66 | 866 | 4 | 9 | 79 | 0 | 66 | 6 | 24 | -18 | 78 | 0.62 | |
| Matt Flynn | GB | 5 | 33 | 518 | 6 | 2 | -6 | 1 | 33 | 3 | 42 | -4 | 74 | 0.59 | |
| Jake Locker | TEN | 5 | 34 | 542 | 4 | 0 | 56 | 1 | 34 | 4 | 30 | 0 | 68 | 0.54 | |
| Kellen Clemens | STL | 3 | 48 | 546 | 2 | 1 | 37 | 1 | 48 | 4 | 18 | -2 | 68 | 0.54 | |
| Seneca Wallace | CLE | 6 | 55 | 567 | 2 | 2 | 70 | 0 | 55 | 4 | 12 | -4 | 67 | 0.53 | |
| Joe Webb | MIN | 10 | 34 | 376 | 3 | 2 | 154 | 2 | 34 | 4 | 30 | -4 | 64 | 0.51 | |
| Kerry Collins | IND | 3 | 48 | 481 | 2 | 1 | -1 | 0 | 48 | 3 | 12 | -2 | 61 | 0.49 | |
| A.J. Feeley | STL | 5 | 53 | 548 | 1 | 2 | 4 | 0 | 53 | 4 | 6 | -4 | 59 | 0.47 | |
| Caleb Hanie | CHI | 6 | 51 | 613 | 3 | 9 | 98 | 0 | 51 | 5 | 18 | -18 | 56 | 0.45 | |
| Josh McCown | CHI | 3 | 35 | 414 | 2 | 4 | 68 | 0 | 35 | 3 | 12 | -8 | 42 | 0.33 | |
| Charlie Whitehurst | SEA | 3 | 27 | 298 | 1 | 1 | 13 | 0 | 27 | 2 | 6 | -2 | 33 | 0.26 | |
| Stephen McGee | DAL | 1 | 24 | 182 | 1 | 0 | 28 | 0 | 24 | 1 | 6 | 0 | 31 | 0.25 | |
| Jake Delhomme | HOU | 1 | 18 | 211 | 1 | 0 | 0 | 0 | 18 | 1 | 6 | 0 | 25 | 0.20 | |
| Luke McCown | JAC | 4 | 30 | 296 | 0 | 4 | 23 | 0 | 30 | 2 | 0 | -8 | 24 | 0.19 | |
| Josh Johnson | TB | 9 | 19 | 246 | 1 | 2 | 67 | 0 | 19 | 2 | 6 | -4 | 23 | 0.18 | |
| Chris Redman | ATL | 5 | 18 | 188 | 0 | 1 | -6 | 0 | 18 | 1 | 0 | -2 | 17 | 0.14 | |
| Matt Leinart | HOU | 2 | 10 | 57 | 1 | 0 | -1 | 0 | 10 | 0 | 6 | 0 | 16 | 0.13 | |
| Richard Bartel | ARI | 2 | 10 | 86 | 1 | 1 | 9 | 0 | 10 | 1 | 6 | -2 | 15 | 0.12 | |
| Charlie Batch | PIT | 3 | 15 | 208 | 0 | 1 | -2 | 0 | 15 | 1 | 0 | -2 | 14 | 0.11 | |
| Bruce Gradkowski | CIN | 2 | 8 | 109 | 1 | 1 | 1 | 0 | 8 | 1 | 6 | -2 | 13 | 0.10 | |
| Kyle Boller | OAK | 2 | 15 | 161 | 0 | 3 | 38 | 0 | 15 | 1 | 0 | -6 | 10 | 0.08 | |
| Jon Kitna | DAL | 3 | 6 | 87 | 1 | 2 | -2 | 0 | 6 | 1 | 6 | -4 | 9 | 0.07 | |
| Mike Kafka | PHI | 5 | 11 | 107 | 0 | 2 | 0 | 0 | 11 | 1 | 0 | -4 | 8 | 0.06 | |
| J.P. Losman | MIA | 2 | 6 | 60 | 0 | 0 | 1 | 0 | 6 | 0 | 0 | 0 | 6 | 0.05 | |
| Chase Daniel | NO | 16 | 4 | 29 | 0 | 0 | -3 | 0 | 4 | 0 | 0 | 0 | 4 | 0.03 | |
| Colin Kaepernick | SF | 3 | 3 | 35 | 0 | 0 | -2 | 0 | 3 | 0 | 0 | 0 | 3 | 0.02 | |
| Shaun Hill | DET | 2 | 2 | 33 | 0 | 0 | -1 | 0 | 2 | 0 | 0 | 0 | 2 | 0.02 | |
| Brian Hoyer | NE | 3 | 1 | 22 | 0 | 0 | -2 | 0 | 1 | 0 | 0 | 0 | 1 | 0.01 | |
| Mark Brunell | NYJ | 16 | 1 | 27 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0.01 | |
| Tyler Thigpen | BUF | 3 | 3 | 25 | 0 | 1 | 8 | 0 | 3 | 0 | 0 | -2 | 1 | 0.01 | |
| Tyrod Taylor | BAL | 3 | 1 | 18 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 1 | 0.01 | |
| Billy Volek | SD | 2 | 0 | 0 | 0 | 0 | -5 | 0 | 0 | 0 | 0 | 0 | 0 | 0.01 | |
| Derek Anderson | CAR | 2 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 0 | 0.01 | |
| Jeff Garcia | SD | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.01 | |
| Rudy Carpenter | TB | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.01 | |
| Terrelle Pryor | OAK | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.01 | |
| Tom Brandstater | STL | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.01 | |