| QUARTERBACKS | passing | rushing | Totals | ||||||||||||
| Name | Team | G | Comp | Yds | TD | Int | Yds | TD | Comp | Yds | TD | Int | Total | Salary | |
| 1 | Tom Brady | NWE | 16 | 398 | 4806 | 50 | 8 | 98 | 2 | 398 | 32.7 | 312 | -16 | 726.7 | 6.52 |
| 2 | Drew Brees | NOR | 16 | 440 | 4423 | 28 | 18 | 52 | 1 | 440 | 29.8 | 174 | -36 | 607.8 | 5.45 |
| 3 | Tony Romo | DAL | 16 | 335 | 4211 | 36 | 19 | 129 | 2 | 335 | 28.9 | 228 | -38 | 553.9 | 4.97 |
| 4 | Peyton Manning | IND | 16 | 337 | 4040 | 31 | 14 | -5 | 3 | 337 | 26.9 | 204 | -28 | 539.9 | 4.84 |
| 5 | Matt Hasselbeck | SEA | 16 | 352 | 3966 | 28 | 12 | 89 | 0 | 352 | 27 | 168 | -24 | 523.0 | 4.69 |
| 6 | Carson Palmer | CIN | 16 | 373 | 4131 | 26 | 20 | 10 | 0 | 373 | 27.6 | 156 | -40 | 516.6 | 4.63 |
| 7 | Derek Anderson | CLE | 16 | 298 | 3787 | 29 | 19 | 70 | 3 | 298 | 25.7 | 192 | -38 | 477.7 | 4.28 |
| 8 | Ben Roethlisberger | PIT | 15 | 264 | 3154 | 32 | 11 | 204 | 2 | 264 | 22.4 | 204 | -22 | 468.4 | 4.20 |
| 9 | Jon Kitna | DET | 16 | 355 | 4068 | 18 | 20 | 63 | 0 | 355 | 27.5 | 108 | -40 | 450.5 | 4.04 |
| 10 | Kurt Warner | ARI | 14 | 281 | 3417 | 27 | 17 | 15 | 1 | 281 | 22.9 | 168 | -34 | 437.9 | 3.93 |
| 11 | Eli Manning | NYG | 16 | 297 | 3336 | 23 | 20 | 69 | 1 | 297 | 22.7 | 144 | -40 | 423.7 | 3.80 |
| 12 | Jay Cutler | DEN | 16 | 297 | 3497 | 20 | 14 | 205 | 1 | 297 | 24.7 | 126 | -28 | 419.7 | 3.76 |
| 13 | Donovan McNabb | PHI | 14 | 291 | 3324 | 19 | 7 | 236 | 0 | 291 | 23.7 | 114 | -14 | 414.7 | 3.72 |
| 14 | Philip Rivers | SDG | 16 | 277 | 3152 | 21 | 15 | 33 | 1 | 277 | 21.2 | 132 | -30 | 400.2 | 3.59 |
| 15 | David Garrard | JAC | 12 | 208 | 2509 | 18 | 3 | 185 | 1 | 208 | 18 | 114 | -6 | 334.0 | 2.99 |
| 16 | Jason Campbell | WAS | 13 | 250 | 2700 | 12 | 11 | 185 | 1 | 250 | 19.2 | 78 | -22 | 325.2 | 2.92 |
| 17 | Jeff Garcia | TAM | 13 | 209 | 2440 | 13 | 4 | 116 | 1 | 209 | 17 | 84 | -8 | 302.0 | 2.71 |
| 18 | Vince Young | TEN | 15 | 238 | 2546 | 9 | 17 | 395 | 3 | 238 | 19.6 | 72 | -34 | 295.6 | 2.65 |
| 19 | Marc Bulger | STL | 12 | 221 | 2392 | 11 | 15 | 13 | 0 | 221 | 16 | 66 | -30 | 273.0 | 2.45 |
| 20 | Damon Huard | KAN | 11 | 206 | 2257 | 11 | 13 | -1 | 0 | 206 | 15 | 66 | -26 | 261.0 | 2.34 |
| 21 | Joey Harrington | ATL | 12 | 215 | 2215 | 7 | 8 | 33 | 0 | 215 | 15 | 42 | -16 | 256.0 | 2.30 |
| 22 | Matt Schaub | HOU | 11 | 192 | 2241 | 9 | 9 | 52 | 0 | 192 | 15.3 | 54 | -18 | 243.3 | 2.18 |
| 23 | Chad Pennington | NYJ | 9 | 179 | 1765 | 10 | 9 | 32 | 1 | 179 | 12 | 66 | -18 | 239.0 | 2.14 |
| 24 | Sage Rosenfels | HOU | 9 | 154 | 1684 | 15 | 12 | 51 | 1 | 154 | 11.6 | 96 | -24 | 237.6 | 2.13 |
| 25 | Cleo Lemon | MIA | 9 | 173 | 1773 | 6 | 6 | 102 | 4 | 173 | 12.5 | 60 | -12 | 233.5 | 2.09 |
| 26 | Tarvaris Jackson | MIN | 12 | 171 | 1911 | 9 | 12 | 260 | 3 | 171 | 14.5 | 72 | -24 | 233.5 | 2.09 |
| 27 | Kyle Boller | BAL | 12 | 168 | 1743 | 9 | 10 | 89 | 0 | 168 | 12.2 | 54 | -20 | 214.2 | 1.92 |
| 28 | Brian Griese | CHI | 7 | 161 | 1803 | 10 | 12 | 28 | 0 | 161 | 12.2 | 60 | -24 | 209.2 | 1.88 |
| 29 | Trent Edwards | BUF | 10 | 151 | 1630 | 7 | 8 | 49 | 0 | 151 | 11.2 | 42 | -16 | 188.2 | 1.69 |
| 30 | Brodie Croyle | KAN | 9 | 127 | 1227 | 6 | 6 | 18 | 0 | 127 | 8.3 | 36 | -12 | 159.3 | 1.43 |
| 31 | Josh McCown | OAK | 9 | 111 | 1151 | 10 | 11 | 143 | 0 | 111 | 8.63 | 60 | -22 | 157.6 | 1.41 |
| 32 | Kellen Clemens | NYJ | 10 | 130 | 1529 | 5 | 10 | 111 | 1 | 130 | 10.9 | 36 | -20 | 156.9 | 1.41 |
| 33 | Chris Redman | ATL | 7 | 89 | 1079 | 10 | 5 | 16 | 0 | 89 | 7.3 | 60 | -10 | 146.3 | 1.31 |
| 34 | Steve McNair | BAL | 6 | 133 | 1113 | 2 | 4 | 32 | 0 | 133 | 7.63 | 12 | -8 | 144.6 | 1.30 |
| 35 | Rex Grossman | CHI | 8 | 122 | 1411 | 4 | 7 | 27 | 0 | 122 | 9.59 | 24 | -14 | 141.6 | 1.27 |
| 36 | Trent Dilfer | SFO | 7 | 113 | 1166 | 7 | 12 | 25 | 0 | 113 | 7.94 | 42 | -24 | 138.9 | 1.25 |
| 37 | Quinn Gray | JAC | 8 | 80 | 986 | 10 | 5 | 57 | 0 | 80 | 6.95 | 60 | -10 | 137.0 | 1.23 |
| 38 | J.P. Losman | BUF | 8 | 111 | 1204 | 4 | 6 | 110 | 0 | 111 | 8.76 | 24 | -12 | 131.8 | 1.18 |
| 39 | Luke McCown | TAM | 5 | 94 | 1009 | 5 | 3 | 117 | 0 | 94 | 7.51 | 30 | -6 | 125.5 | 1.13 |
| 40 | Gus Frerotte | STL | 8 | 94 | 1014 | 7 | 12 | 3 | 0 | 94 | 6.78 | 42 | -24 | 118.8 | 1.06 |
| 41 | Vinny Testaverde | CAR | 7 | 94 | 952 | 5 | 6 | 22 | 0 | 94 | 6.49 | 30 | -12 | 118.5 | 1.06 |
| 42 | Trent Green | MIA | 5 | 85 | 987 | 5 | 7 | 32 | 0 | 85 | 6.79 | 30 | -14 | 107.8 | 0.97 |
| 43 | Alex Smith | SFO | 7 | 94 | 914 | 2 | 4 | 89 | 0 | 94 | 6.69 | 12 | -8 | 104.7 | 0.94 |
| 44 | Jake Delhomme | CAR | 3 | 55 | 624 | 8 | 1 | 26 | 0 | 55 | 4.33 | 48 | -2 | 105.3 | 0.94 |
| 45 | Todd Collins | WAS | 4 | 67 | 888 | 5 | 0 | 1 | 0 | 67 | 5.93 | 30 | 0 | 102.9 | 0.92 |
| 46 | Shaun Hill | SFO | 3 | 54 | 501 | 5 | 1 | 14 | 1 | 54 | 3.43 | 36 | -2 | 91.4 | 0.82 |
| 47 | David Carr | CAR | 6 | 73 | 635 | 3 | 5 | 59 | 0 | 73 | 4.63 | 18 | -10 | 85.6 | 0.77 |
| 48 | Matt Moore | CAR | 9 | 63 | 730 | 3 | 5 | 5 | 0 | 63 | 4.9 | 18 | -10 | 75.9 | 0.68 |
| 49 | John Beck | MIA | 5 | 60 | 559 | 1 | 3 | 12 | 1 | 60 | 3.81 | 12 | -6 | 69.8 | 0.63 |
| 50 | Matt Leinart | ARI | 5 | 60 | 647 | 2 | 4 | 42 | 0 | 60 | 4.59 | 12 | -8 | 68.6 | 0.62 |
| 51 | Troy Smith | BAL | 4 | 40 | 452 | 2 | 0 | 54 | 1 | 40 | 3.37 | 18 | 0 | 61.4 | 0.55 |
| 52 | Kyle Orton | CHI | 3 | 43 | 478 | 3 | 2 | -1 | 0 | 43 | 3.18 | 18 | -4 | 60.2 | 0.54 |
| 53 | Kelly Holcomb | MIN | 3 | 42 | 515 | 2 | 1 | 0 | 0 | 42 | 3.43 | 12 | -2 | 55.4 | 0.50 |
| 54 | Kerry Collins | TEN | 6 | 50 | 531 | 0 | 0 | -3 | 0 | 50 | 3.52 | 0 | 0 | 53.5 | 0.48 |
| 55 | JaMarcus Russell | OAK | 4 | 36 | 373 | 2 | 4 | 4 | 0 | 36 | 2.51 | 12 | -8 | 42.5 | 0.38 |
| 56 | Brooks Bollinger | MIN | 5 | 33 | 391 | 1 | 1 | 18 | 0 | 33 | 2.73 | 6 | -2 | 39.7 | 0.36 |
| 57 | Byron Leftwich | ATL | 3 | 32 | 279 | 1 | 2 | 7 | 0 | 32 | 1.91 | 6 | -4 | 35.9 | 0.32 |
| 58 | Patrick Ramsey | DEN | 2 | 29 | 262 | 1 | 1 | 6 | 0 | 29 | 1.79 | 6 | -2 | 34.8 | 0.31 |
| 59 | Seneca Wallace | SEA | 10 | 19 | 215 | 2 | 1 | 17 | 0 | 19 | 1.55 | 12 | -2 | 30.5 | 0.27 |
| 60 | Aaron Rodgers | GNB | 2 | 20 | 218 | 1 | 0 | 29 | 0 | 20 | 1.65 | 6 | 0 | 27.6 | 0.25 |
| 61 | Tim Rattay | ARI | 4 | 15 | 164 | 3 | 3 | 5 | 0 | 15 | 1.13 | 18 | -6 | 28.1 | 0.25 |
| 62 | Charlie Batch | PIT | 7 | 17 | 232 | 2 | 3 | -7 | 0 | 17 | 1.5 | 12 | -6 | 24.5 | 0.22 |
| 63 | Jim Sorgi | IND | 4 | 18 | 132 | 1 | 0 | -4 | 0 | 18 | 0.85 | 6 | 0 | 24.9 | 0.22 |
| 64 | Chris Weinke | SFO | 2 | 13 | 104 | 1 | 0 | 0 | 0 | 13 | 0.69 | 6 | 0 | 19.7 | 0.18 |
| 65 | Brock Berlin | STL | 1 | 17 | 153 | 0 | 1 | -16 | 0 | 17 | 0.91 | 0 | -2 | 15.9 | 0.14 |
| 66 | J.T. O'Sullivan | DET | 5 | 13 | 148 | 1 | 2 | -10 | 0 | 13 | 0.92 | 6 | -4 | 15.9 | 0.14 |
| 67 | Craig Nall | GNB | 1 | 7 | 88 | 1 | 0 | 6 | 0 | 7 | 0.63 | 6 | 0 | 13.6 | 0.12 |
| 68 | Bruce Gradkowski | TAM | 4 | 13 | 130 | 0 | 1 | 20 | 0 | 13 | 1 | 0 | -2 | 12.0 | 0.11 |
| 69 | Brad Johnson | DAL | 16 | 7 | 79 | 0 | 0 | -5 | 0 | 7 | 0.49 | 0 | 0 | 7.5 | 0.07 |
| 70 | Matt Cassel | NWE | 6 | 4 | 38 | 0 | 1 | 12 | 1 | 4 | 0.33 | 6 | -2 | 8.3 | 0.07 |
| 71 | Andrew Walter | OAK | 1 | 5 | 38 | 0 | 0 | 0 | 0 | 5 | 0.25 | 0 | 0 | 5.3 | 0.05 |
| 72 | Jared Lorenzen | NYG | 2 | 4 | 28 | 0 | 0 | 2 | 0 | 4 | 0.2 | 0 | 0 | 4.2 | 0.04 |
| 73 | Brady Quinn | CLE | 1 | 3 | 45 | 0 | 0 | 0 | 0 | 3 | 0.3 | 0 | 0 | 3.3 | 0.03 |
| 74 | Charlie Frye | CLE | 1 | 4 | 34 | 0 | 1 | 1 | 0 | 4 | 0.23 | 0 | -2 | 2.2 | 0.02 |
| 75 | Jamie Martin | NOR | 4 | 0 | 0 | 0 | 0 | -3 | 0 | 0 | -0 | 0 | 0 | 0.0 | 0.01 |
| 76 | Kevin Kolb | PHI | 1 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | -0 | 0 | 0 | 0.0 | 0.01 |
| 77 | Tim Hasselbeck | ARI | 1 | 0 | 0 | 0 | 0 | -1 | 0 | 0 | -0 | 0 | 0 | 0.0 | 0.01 |
| 78 | Tyler Thigpen | KAN | 1 | 2 | 41 | 0 | 1 | 0 | 0 | 2 | 0.27 | 0 | -2 | 0.3 | 0.01 |
| 79 | Anthony Wright | NYG | 4 | 1 | 12 | 0 | 0 | -1 | 0 | 1 | 0.07 | 0 | 0 | 1.1 | 0.01 |
| 80 | Matt Gutierrez | NWE | 5 | 1 | 15 | 0 | 0 | -13 | 0 | 1 | 0.01 | 0 | 0 | 1.0 | 0.01 |
| 81 | Billy Volek | SDG | 5 | 3 | 6 | 0 | 1 | -7 | 0 | 3 | -0 | 0 | -2 | 1.0 | 0.01 |